Making Concentrated Pterostilbene Highly Bioavailable in Pressure Processed Phospholipid Nanoemulsion

Pterostilbene, a dimethylether analog of resveratrol, has been found to have potent biological activity. However, the bioavailability pterostilbene in system is limited due its poor solubility an aqueous environment. A nanoemulsion was designed for this purpose. Lecithin-based formed after 3 cycles through high-pressure homogenizer at 500 psi. The rheological properties and particle size were measured using dynamic light scattering viscometer. storage stabilities prepared formulation determined based on ability maintain loading concentration. According experimental results, lecithin-based contained approximately 9.5% pterostilbene. Over 28-day stability test, size, zeta potential, encapsulation did not change significantly, indicating good stability. positive effect studied confirmed vitro lipolysis caco-2 monolayer model.